Chronic lack of exercise — dubbed "exercise deficiency" — is associated with cardiac atrophy, reduced cardiac output and chamber size, and diminished cardiorespiratory fitness (CRF) in a subgroup of patients with heart failure with preserved ejection fraction (HFpEF), researchers say.
Increasing the physical activity levels of these sedentary individuals could be an effective preventive strategy, particularly for those who are younger and middle-aged, they suggest.
Thinking of HFpEF as an exercise deficiency syndrome leading to a small heart "flies in the face of decades of cardiovascular teaching, because traditionally, we've thought of heart failure as the big floppy heart," Andre La Gerche, MBBS, PhD, of the Baker Heart and Diabetes Institute in Melbour...
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