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Researchers Using Bioluminescent Imaging Technology Find Link Between Arbitrary Use Vitamin B3 Supplements and Cancer


Representative Image (IANS)

Representational Image

(IANS)

New research from the University of Missouri in the U.S. has found that common vitamin B3 dietary supplements can increase the risk of serious disease, including developing cancer.

While previous studies have linked commercial dietary supplements like nicotinamide riboside (NR), a form of vitamin B3, to cardiovascular, metabolic and neurological health benefits, new research has warned against its arbitrary use.

The researchers made the discovery while using bioluminescent imaging technology to study how nicotinamide riboside supplements work inside the body.

The international team of researchers led by Elena Goun, an associate professor of chemistry at the University of Missouri, discovered that high levels of NR could increase someone’s risk of developing triple-negative breast cancer and cause cancer to metastasise or spread to the brain.

Once cancer reaches the brain, the results are deadly because no viable treatment options exist at this time, said Goun, the corresponding author of the study published in the journal Biosensors and Bioelectronics.

“Some people take them (vitamins and supplements) because they automatically assume that vitamins and supplements only have positive health benefits, but very little is known about how they actually work,” Goun said.

Since NR is a known supplement for helping increase cellular energy levels, and cancer cells feed off of that energy with their increased metabolism, Goun wanted to investigate NR’s role in the development and spread of cancer.

“Our work is especially important given the wide commercial availability and a large number of ongoing human clinical trials where NR is used to mitigate the side effects of cancer therapy in patients,” Goun said.

The researchers used this technology to compare and examine how much NR levels were present in cancer cells, T cells and healthy tissues.

The findings emphasise the importance of careful investigations of potential side effects for supplements like NR prior to their use in people with different types of health conditions.

In the future, Goun would like to provide information that could potentially lead to the development of specific inhibitors to help make cancer therapies like chemotherapy more effective in treating cancer.

“Not all cancers are the same in every person, especially from the standpoint of metabolic signatures,” Goun said. “Often times cancers can even change their metabolism before or after chemotherapy.”

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The above article has been published from a wire source with minimal modifications to the headline and text.



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