Repare Therapeutics to Highlight Program Progress for RP-6306 at Today’s Virtual Investor Day Event

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-Business highlights pre-clinical anti-tumor activity of RP-6306, a first-in-class, selective, oral inhibitor of PKMYT1, which is artificial deadly with CCNE1 amplification and other genomic anomalies-

– Initiation of Stage 1 medical trial registration for RP-6306 prepared for to start throughout this quarter-

-Teleconference and webcast on Thursday, April 8 at 10:30 a.m. ET will include scholastic specialists Carol Aghajanian, M.D. and Timothy Yap, MBBS, Ph.D., FRCP-

CAMBRIDGE, Mass. & MONTREAL — Repare Rehabs Inc. (“Repare” or the “Company”) (Nasdaq: RPTX), a leading clinical-stage accuracy oncology business made it possible for by its exclusive artificial lethality method to the discovery and advancement of unique therapies, will host a virtual Financier Day webcast today from 10:30 a.m. – 12:00 p.m. ET, highlighting the development of its exclusive RP-6306 program for growths with hereditary changes identified by CCNE1 amplification. The Business anticipates to start a Stage 1 medical trial of RP-6306 in the 2nd quarter of 2021.

“At today’s event, we will be reviewing the compelling pre-clinical anti-tumor activity of RP-6306, our first- in-class, selective, oral inhibitor of PKMYT1 to treat CCNE1-amplified, FBXW7-altered and other undisclosed PKMYT1 inhibitor-sensitive cancers. Our in vivo and other pre-clinical data indicate that RP-6306 can selectively inhibit tumors with these specific alterations when used as a monotherapy and in combination with other agents. We plan to initiate a Phase 1 clinical trial during this quarter, which is a quarter ahead of previously announced guidance,” stated Lloyd M. Segal, President and Ceo of Repare. “We look forward to advancing our RP-6306 program into the clinic.”

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“There is a high unmet medical need for better treatments for patients with homologous recombinant-proficient cancers. The incidence of such cancers is rising and represents a growing therapeutic challenge,” stated Maria Koehler, MD, PhD, Chief Medical Officer of Repare. “Targeting DNA damage repair using synthetic lethal strategies is a massive opportunity to build on the success of PARP inhibitors. The field is rapidly expanding beyond PARP inhibitors and has been accelerated by the discovery of novel targets enabled by cancer genome sequencing and CRISPR technologies.”

Emphasizes from the Virtual Financier Day

Pre-Clinical Data Findings
Utilizing its proprietary, CRISPR-based SNIPRx discovery platform, Repare has actually determined PKMYT1 as a strong hit in a CCNE1-overexpression artificial deadly screen. PKMYT1 is a kinase that phosphorylates CDK1, consequently holding the cyclin B-CDK1 complex in a non-active state till the cell is prepared to get in mitosis. The Business’s item prospect RP-6306 is being established as an extremely powerful and selective PKMYT1 inhibitor that preferentially eliminates growth cells overexpressing CCNE1 and has actually revealed to hinder the development of a broad series of CCNE1-amplified growths in xenograft/PDX preclinical designs, both as a single representative and in mix treatment settings. RP-6306 has actually been observed to have a beneficial pre-clinical PK profile in addition to low capacity for drug-drug interactions. Application of Repare’s ACTION2 genome-wide chemical screen has actually determined other gene changes beyond CCNE1 amplification that are distinctively targetable by RP-6306, consisting of growths that have loss of FBXW7 function, a cell-cycle regulator that has actually been linked as a crucial hereditary chauffeur in a broad series of cancers, and represent additional locations of unmet medical requirement.

RP-6306 Stage 1 Medical Trial Style
Repare strategies to start registration of a Stage 1 medical trial of RP-6306 throughout this quarter. Research study goals consist of evaluation of security, tolerability, dosage and schedule (consisting of the advised Stage 2 dosage). Topic to conclusion and evaluation of the Stage 1 medical trial, the Business anticipates to advance RP-6306, both as monotherapy and in mix with chemotherapies and other representatives, into proof-of-concept research studies in 2022 targeting a range of client populations, consisting of those with growths with CCNE1 amplification, FBXW7 loss or other concealed changes determined through its exclusive ACTION2 screen. Potential enrichment of research study client populations will be assisted by its continuous efforts to establish client choice biomarkers covering both target engagement and practical (DNA damage) readouts.

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Virtual Financier Day Program

10:30 a.m. – 10:35 a.m. ET
Intro
Lloyd Segal, President and Ceo, Repare Therapy

10:35 a.m. – 10:50 a.m. ET
Targeting DNA Damage Repair Work in the Center
Timothy Yap, MBBS, Ph.D., FRCP
Medical Director, Institute for Applied Cancer Science, and Partner Teacher, Department of Investigational Cancer Rehabs, Department of Cancer Medication at MD Anderson Cancer Center

10:50 a.m. – 11:05 a.m. ET
Genomic Categories of Endometrial & Ovarian Cancers is Requirement of Care
Unmet Requirement: Treatments Targeting CCNE1 & FBXW7
Carol Aghajanian, M.D.
Chief of Gynecologic Medical Oncology Service and Teacher of Medication, Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center

11:05 a.m. – 11:35 a.m. ET
Target Discovery & Biology of RP-6306 & ACTION Characterization Table
Michael Zinda, Ph.D., Executive Vice President, Chief Scientific Officer, Repare Therapy

11:35 a.m. – 11:45 a.m. ET
Translational & Medical Prepare For RP-6306
Maria Koehler, M.D., Ph.D., Executive Vice President, Chief Medical Officer, Repare Therapy

11:45 a.m. – 12:00 p.m. ET
Conclusion & Q&A Session

Teleconference and Webcast

To access the occasion virtual occasion, please dial (833) 638-9655 (U.S. and Canada) or (602) 585-9856 (global) a minimum of 10 minutes prior to the start time and describe conference ID 1093819. A live video webcast will be offered in the Financier area of the Business’s site at https://ir.reparerx.com/news-and-events/events. A webcast replay will likewise be offered on the business site at the conclusion of the call.

About RP-6306

RP-6306, the outcome of Repare’s exclusive drug discovery program, is a first-in-class, selective, oral inhibitor of PKMYT1 to deal with CCNE1-amplified, FBXW7-altered and other PKMYT1 inhibitor-sensitive cancers that generally do not react well to platinum or PARP inhibitor treatment. Through Repare’s SNIPRx screen project for targets that are SL with CCNE1 amplification, the Business determined and verified this unique SL gene that has the qualities of a restorative target. Consequently, the Business established unique and selective inhibitors versus PKMYT1, which consistently showed engaging anti-tumor activity, and revealed the development of a medical prospect for this first-in-class program. Repare expects starting a Stage 1 medical trial of RP-6306 throughout the quarter ending June 30, 2021. This trial is anticipated to enlist clients experiencing persistent growths identified by CCNE1 amplification or other genomic changes anticipated to be conscious RP-6306. The main goal of the trial is to evaluate initial security in clients and to develop the RP2D and schedule for RP-6306 for additional research studies as a monotherapy . Based on Stage 1 outcome, an extra trial is prepared to assess the mix of RP-6306 with authorized anti-cancer representatives, consisting of chemotherapy.

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About Repare Therapy, Inc.

Repare Rehabs is a leading clinical-stage accuracy oncology business made it possible for by its exclusive artificial lethality method to the discovery and advancement of unique therapies. The Business uses its genome-wide, CRISPR-enabled SNIPRx® platform to methodically find and establish extremely targeted cancer treatments concentrated on genomic instability, consisting of DNA damage repair work. The Business’s pipeline includes its lead item prospect RP-3500, a possible best-in-class ATR inhibitor presently in Stage 1/2 medical advancement, in addition to RP-6306, a first-in-class, selective, oral inhibitor of PKMYT1 to deal with CCNE1-amplified, FBXW7-altered and other PKMYT1 inhibitor-sensitive cancers, and a Polθ inhibitor program. To find out more, please go to reparerx.com.

SNIPRx® is a signed up hallmark of Repare Rehabs Inc.

Positive Declarations

This news release includes “forward-looking statements” within the significance of the Personal Securities Lawsuits Reform Act of 1995. All declarations in this news release besides declarations of historic truths are “forward-looking statements. These statements may be identified by words such as “aims,” “anticipates,” “believes,” “could,” “estimates,” “expects,” “forecasts,” “goal,” “intends,” “may,” “plans,” “possible,” “potential,” “seeks,” “will” and variations of these words or comparable expressions that are planned to determine positive declarations, although not all positive declarations consist of these words. Positive declarations in this news release consist of, however are not restricted to, the medical advancement of RP-6306 consisting of the initiation, timing, style and outcomes of the Stage 1 medical trial of RP-6306; the effectiveness of RP-6306 as a monotherapy or in mix with other treatments; and the Business’s capability to determine and establish extra item prospects utilizing its SNIPRx platform. These positive declarations are based upon the Business’s expectations and presumptions since the date of this news release. Each of these positive declarations includes dangers and unpredictabilities that might trigger the Business’s medical advancement programs, future outcomes or efficiency to vary materially from those revealed or indicated by the positive declarations. Numerous aspects might trigger distinctions in between existing expectations and real outcomes, consisting of the effects of the COVID-19 pandemic on the Business’s service, medical trials and monetary position, unforeseen security or effectiveness information observed throughout preclinical research studies or medical trials, medical trial website activation or registration rates that are lower than anticipated, modifications in anticipated or existing competitors, modifications in the regulative environment, the unpredictabilities and timing of the regulative approval procedure, and unforeseen lawsuits or other disagreements. Other aspects that might trigger the Business’s real outcomes to vary from those revealed or indicated in the positive declarations in this news release are determined in the area entitled “Risk Factors” in the Business’s Yearly Report on Type 10-K for the year ended December 31, 2020 submitted with the Securities and Exchange Commission (“SEC”) on March 4, 2021. The Business specifically disclaims any responsibility to upgrade any positive declarations consisted of herein, whether as an outcome of any brand-new info, future occasions, altered scenarios or otherwise, other than as otherwise needed by law.

View source variation on businesswire.com: https://www.businesswire.com/news/home/20210408005578/en/

Contacts

Repare:
Steve Strength
Chief Financial Officer
Repare Rehabs Inc.
info@reparerx.com

Financiers:
Argot Partners
repare@argotpartners.com
212-600-1902

Media:
David Rosen
Argot Partners
david.rosen@argotpartners.com
212-600-1902

#distro

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Jobber Wiki author Frank Long contributed to this report.