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NFL Week 6 Predictions: Our Picks for Each Game

The Bengals’ defense is a far cry from the Seahawks’, however: No opponent has scored more than 23 points, and all three of Cincinnati’s losses have been by a field goal or less. Pick: Bengals -1.5

Tampa Bay Buccaneers (3-2) at Pittsburgh Steelers (1-4), 1 p.m., Fox

Line: Steelers +8.5 | Total: 44

After Pittsburgh was trounced by the Bills on Sunday, one-way action on Tampa Bay moved the line on this game from 6.5 to as many as 9 points as of Wednesday. Somewhere along the way, there has been buyback on the Steelers, as the line has fluctuated and continues to be priced differently across the market.

Last week, as 14-point underdogs the Steelers failed to cover the largest point spread of the season (and the largest in their team’s history). This week, Pittsburgh doesn’t get nearly that many points, but it may not need them. They’re up against the Buccaneers, who have only passed for seven touchdowns all season. Pick: Steelers +8.5

Carolina Panthers (1-4) at Los Angeles Rams (2-3), 4:05 p.m., Fox

Line: Rams -10.5 | Total: 40.5

Coach Matt Rhule was fired on Monday after the Panthers lost the tenth of their last 11 games. Steve Wilks stepped in as interim coach and immediately fired special teams coach Ed Foley and defensive coordinator Phil Snow, saying he wanted to get a “different approach moving forward.” Wilks will need one. Baker Mayfield is out for the near future with a high ankle sprain leaving P.J. Walker to make his third ever N.F.L. start.

Carolina’s one glimmer of hope lies with Los Angeles’s offensive line, which has been a revolving door all season. Their issues up front have been a major contributor to Matthew Stafford’s back-and-forth duel with Matt Ryan for the dubious honor of the most sacks and turnovers in the league. The Panthers are getting 10.5 points in the biggest spread of the week, and so far the bettors have been eager to take them. Pick: Panthers +10.5

Arizona Cardinals (2-3) at Seattle Seahawks (2-3), 4:05 p.m., Fox

Line: Seahawks +3 | Total: 51

The Seahawks have one of the league’s worst defenses, giving up 30.8 points per game. The Cardinals are better than most of the teams that have rolled over Seattle, but they have yet to win a home game. Arizona enters the game as road favorites against one of the biggest home-field advantages in the N.F.L., a boost that could mean a lot. Pick: Seahawks +3

Denver Broncos (2-3) at Los Angeles Chargers (3-2), 8:15 p.m., ESPN

Line: Chargers -5.5 | Total: 45.5

Russell Wilson has a partially torn muscle affecting his throwing shoulder but plans to play after getting a plasma injection to relieve pain. But Denver lost at home last week to the Colts in one of the ugliest games of the season, a bad defeat that gives no indication the Broncos can challenge the Chargers, a top-10 scoring team.

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