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49ers vs. Bears prediction, odds, line, spread: 2022 NFL picks, Week 1 best bets from proven computer model


The San Francisco 49ers hit the road to take on the Chicago Bears in a NFL Week 1 matchup at 1 p.m. ET on Sunday at Soldier Field. The Niners are looking to build off a trip to the NFC Championship Game in 2021, but will be transitioning to Trey Lance as their new full-time starting quarterback. The Bears will be guided by first-year head coach Matt Eberflus and will be leaning on quarterback Justin Fields to take a big step in his second NFL season. San Francisco leads the all-time series 35-32-1.

San Francisco is favored by 7 points in the latest Bears vs. 49ers odds from Caesars Sportsbook, and the over/under is set at 41.5. Before making any 49ers vs. Bears picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Bears vs. 49ers and just locked in its picks and NFL Week 1 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Niners vs. Bears:

  • Bears vs. 49ers spread: 49ers -7
  • Bears vs. 49ers over/under: 42 points
  • Bears vs. 49ers picks: See picks here

Featured Game | Chicago Bears vs. San Francisco 49ers

Why the Bears can cover

The Bears have high hopes for Fields, who flashed glimpses of having high-level NFL starter ability as a rookie in 2021. Wide receiver Darnell Mooney emerged as the Bears top target a year ago, and has Pro Bowl potential on the outside. 

Roquan Smith ended his holdout and returned to the team in time for the regular season. The two-time All-Pro is one of the best linebackers in the league, and his presence instantly elevates the Chicago defense. Defensive end Robert Quinn is coming off a stellar 2021 campaign where he tallied 18.5 sacks.

Why the 49ers can cover

The Niners are among the top early season Super Bowl contenders in the NFC. Kyle Shanahan has proven to be one of the best head coaches and game managers in the league. Lance may be inexperienced, but Shanahan will likely keep him out of as many unfavorable situations as possible. 

Deebo Samuel remains one of the most explosive offensive playmakers in the league, and George Kittle, who is listed as questionable (groin), is an All-Pro caliber tight end. Defensively, the Niners are outstanding up front, with Nick Bosa, Arik Armstead, and Fred Warner all elite at their respective positions. 

How to make Bears vs. 49ers picks

The model has simulated Bears vs. 49ers 10,000 times and the results are in. It is leaning Over on the point total, and it’s also generated a point-spread pick that is hitting in more than 50% of simulations. You can only see the model’s 49ers vs. Bears pick at SportsLine.

So who wins 49ers vs. Bears on Sunday? And which side of the spread is hitting over 50% of the time? Visit SportsLine right now to find out which side of the Bears vs. 49ers spread you should be all over Sunday, all from the model on a 138-97 roll on its top-rated NFL picks, and find out.





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